Promise of cancer stem cell vaccine

作者:Zhou, Li; Lu, Lin; Wicha, Max S.; Chang, Alfred E.; Xia, Jian-chuan; Ren, Xiubao*; Li, Qiao
来源:Human Vaccines & Immunotherapeutics, 2015, 11(12): 2796-2799.
DOI:10.1080/21645515.2015.1083661

摘要

Dendritic cell (DC)-based vaccines designed to target cancer stem cells (CSC) can induce significant antitumor responses via conferring host anti-CSC immunity. Our recent studies have demonstrated that CSC-DC vaccine could inhibit metastasis of primary tumors and induce humoral immune responses against cancer stem cells. This approach highlights the promise of cancer stem cell vaccine in cancer immunotherapy.