A mild, efficient and one-pot synthesis of 2-substituted benzimidazoles by ZrOCl(2).8H(2)O catalyzed ring closure reaction

作者：Reddy Ch Sanjeeva^*; Nagaraj A

来源：Indian Journal of Chemistry - Section B: Organic and Medicinal Chemistry , 2008, 47(7): 1154-1159.

• ZrOCl(2).8H(2)O
• benzimidazole
• orthoester
• microwave irradiation

A mild, efficient and one-pot synthesis of an array of 2-substituted benzimidazoles from an appropriate o-phenylenediamine and orthoesters such as orthoformate, orthoacetate and orthovalerate using ZrOCl(2).8H(2)O. at room temperature and under microwave irradiation is described. Ecofriendly, solvent-Free methodology has been employed under microwave condition. Compared with the conventional method, microwave irradiation method has the advantages of excellent yields (81-93%) and shorter reaction time (5-10 min).

• 出版日期2008-7