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摘要
Purpose: To evaluate the feasibility of three-dimensional (3D) steady state free precession (SSFP) magnetic resonance angiography (MRA) using nonselective radiofrequency excitation for the assessment of thoracic central veins.
Materials and Methods: Thirty consecutive patients (17 males, 13 females. age range 22-76) with various cardiac and thoracic vascular diseases underwent free-breathing electrocardiogram-gated non-contrast SSFP MRA and conventional high-resolution 3D contrast-enhanced (CE) MRA of the thorax at 1.5 T. Two readers evaluated both datasets for findings: venous visibility and sharpness (from 0, not visualized to 3, excellent definition); artifacts-, signal-to-noise ratio (SNR); and contrast-to-noise ratio (CNR) in 8 venous segments including superior vena cava (SVC), supra-diaphragmatic inferior vena cava. bilateral brachiocephalic, proximal subclavian, and lower internal jugular veins. Statistical analysis was performed using Wilcoxon test for overall image quality and vessel visibility, t test for SNR and CNR analysis, and kappa coefficient for inter-observer variability.
Results: 3D SSFP and CE-MRA were successfully performed in all patients. Scan time for SSFP MRA ranged from 5 to 10 minutes (mean +/- standard deviation, 7 +/- 2 minutes). Reader 1 (2) graded the overall image quality as excellent and good on SSFP MRA in 23 (25) and 7 (5) patients, and on CE-MRA in 22 (23) and 8 (9) patients, respectively. On SSFP MRA, readers 1 and 2 graded 234 (97.5%) and 233 (97.1%) venous segments with diagnostic definition (grades 2 and 3) (kappa = 0.69), respectively. On conventional CE-MRA, readers 1 and 2 graded 231 (96.3%) and 232 (96.7%) venous segments with diagnostic definition (grades 2 and 3) (kappa = 0.68), respectively. Segmental visibility and sharpness were higher for lower internal jugular veins on CE-MRA for each reader (P < 0.001). No significant difference existed for venous visibility and sharpness scores for other venous segments between the 2 techniques for both readers (P > 0.05). SNR and CNR values were lower for internal jugular veins on SSFP MRA (P < 0.001). No significant difference existed between SNR and CNR values for the other venous segments on SSFP and CE-MRA (P > 0.05 for all). The 2 readers demonstrated patent SVC Glenn shunt to main pulmonary artery (n = 3), patent extra cardiac Fontan shunt from inferior vena cava to pulmonary artery confluence (n = 2), and dilatation and thrombosis of SVC (n = 1) and right brachiocephalic vein (n = 1) on both datasets.
Conclusion: Free breathing navigator-gated noncontrast 3D SSFP MRA with nonselective radiofrequency excitation provides high image quality and sufficient SNR and CNR for confident evaluation of thoracic central veins.
- 出版日期2008-5
