Acrolein metabolites, diabetes and insulin resistance

作者：Feroe Aliya G; Attanasio Roberta; Scinicariello Franco

来源：Environmental Research, 2016, 148: 1-6.

DOI：10.1016/j.envres.2016.03.015

• N-acetyl-S-(Carboxyethyl)-l-cysteine
• N-acetyl-S-(3-Hydroxypropyl)-l-cysteine
• NHANES
• HOMA

Acrolein is a dietary and environmental pollutant that has been associated in vitro to dysregulate glucose transport. We investigated the association of urinary acrolein metabolitesN-acetyl-S-(3-hydroxypropyl)-L-cysteine (3-HPMA) and N-acetyl-S-(carboxyethyl)-L-cysteine (CEMA) and their molar sum (Eacrolein) with diabetes using data from investigated 2027 adults who participated in the 2005-2006 National Health and Nutrition Examination Survey (NHANES). After excluding participants taking insulin or other diabetes medication we, further, investigated the association of the compounds with insulin resistance (n=850), as a categorical outcome expressed by the homeostatic model assessment (HOMA-IR > 2.6). As secondary analyses, we investigated the association of the compounds with HOMA-IR, HOMA-beta, fasting insulin and fasting plasma glucose. The analyses were performed using urinary creatinine as independent variable in the models, and, as sensitivity analyses, the compounds were used as creatinine corrected variables. Diabetes as well as insulin resistance (defined as HOMA-IR > 2.6) were positively associated with the 3-HPMA, CEMA and Sigma(Acrolein) with evidence of a dose-response relationship (p < 0.05). The highest 3rd and 4th quartiles of CEMA compared to the lowest quartile were significantly associated with higher HOMA-IR, HOMA-beta and fasting insulin with a dose-response relationship. The highest 3rd quartile of 3-HPMA and Sigma(Acrolein) were positively and significantly associated with HOMA-IR, HOMA-beta and fasting insulin. These results suggest a need of further studies to fully understand the implications of acrolein with type 2 diabetes and insulin Published by Elsevier Inc.

• 出版日期2016-7