A new player SETs in myeloid malignancy

作者：Trimarchi Thomas^*; Ntziachristos Panagiotis; Aifantis Iannis

来源：Nature Genetics, 2013, 45(8): 846-847.

DOI：10.1038/ng.2709

Recent studies have identified recurrent mutations in SETBP1, the gene that encodes SET-binding protein 1, in several types of myeloid malignancies, including chronic myeloid and acute myeloid leukemias. The identified mutations frequently target the SKI-homologous domain, although the exact pathogenic mechanisms remain unknown.

• 出版日期2013-8