科研之友
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摘要
A convenient one-step process for the preparation of methyl 2-benzamidomethyl-3-oxobutanoate (1), a raw material used in the Synthesis of (2R,3R)-3-((R)-1-(tert-butyldimethylsilyloxy)ethyl)-2,3-dimethyl-4-oxoazetidin-2-yl acetate (2), a key intermediate for carbapenem synthesis is reported. The process is carried out under mild reaction conditions and is amenable to large-scale synthesis.
- 出版日期2009-6
- 单位山东大学
