Association between a p73 Gene Polymorphism and Genetic Susceptibility to Non-small Cell Lung Cancer in the South of China

作者：Wang, Shuang-Shuang; Guo, Hai-Yan; Dong, Lin-Li; Zhu, Xiang-Qian; Liang-Ma; Li, Wen^*; Tang, Jian-Xin

来源：Asian Pacific Journal of Cancer Prevention, 2014, 15(23): 10387-10391.

DOI：10.7314/APJCP.2014.15.23.10387

• NSCLC
• p73 gene polymorphism
• HRM and PCR-CTPP

Background: This study aimed to identify any association between the p73 gene G4C14-to-A4T14 polymorphism and risk of non-small cell lung cancer (NSCLC) in the south of China. Materials and Methods: We genotyped the p73 gene polymorphism of peripheral blood DNA from 168 patients with NSCLC and 195 normal controls using HRM (high resolution melting) and PCR-CTPP (polymerase chain reaction with confronting two-pair primers). Results: The results of genotyping by HRM and PCR-CTPP were consistent with direct sequencing, the p73 genotype distribution in 168 lung cancer patients being as follows: GC/GC 101 cases (60.1%), GC/AT 59 cases (35.1%), AT/AT 8 cases (4.8%). The carriers of AT/AT genotype had a significantly reduced risk of NSCLC (OR=0.370; 95% CI: 0.170-0.806; p=0.010) as compared with non-carriers. However, we found no relations between p73 genotypes and histological type (p=0.798, x(2)=0.452), tumor stage (p=0.806, x(2)=0.806), or lymph node metastasis (p=0.578, x(2)=1.098). Conclusions: Our findings suggest that the p73 G4C14-to-A4T14 polymorphism may be a modifier of NSCLC susceptibility in the Chinese population.

• 出版日期2014
• 单位湖南工业大学; 湖南省肿瘤医院