Azinyl Sulfides - CXVIII. Antimicrobial Activity of Novel 1-Methyl-3-thio-4-aminoquinolinium salts

作者：Zieba A^*; Wojtyczka R D; Kepa M; Idzik D

来源：Folia Microbiologica, 2010, 55(1): 3-9.

Synthesis and antimicrobial activity of novel 1-methyl-3-alkylthio-4-aminoquinolinium salts 2 and 1-methyl-3-acylthio-4-aminoquinolinium salts 4 are described. Compounds 2 were obtained by reacting 1-methyl-3,4-(dimethylthio) quinolinium chloride 1 with amines and by reacting 1-methyl-4-aminoquinolinium- 3-thiolates 3 with alkylating agents. Compounds 4 were obtained by the reaction of 1-methyl-4- aminoquinolinium-3-thiolates 3 with acylating agents. Antimicrobial activity of compounds 2 and 4 was determined using G(+) (Staphylococcus aureus, Enterococcus faecalis) and G(-)(Escherichia coli, Pseudomonas aeruginosa) strains as well as Candida albicans yeast. The compounds show greatest activity against S. aureus whereas the lowest against P. aeruginosa.

• 出版日期2010-1