MUC1 mucin is expressed on human T-regulatory cells: Function in both co-stimulation and co-inhibition

作者：Konowalchuk Jeffrey D; Agrawal Babita^*

来源：Cellular Immunology, 2012, 272(2): 193-199.

DOI：10.1016/j.cellimm.2011.10.012

• T cells
• Regulatory T cells
• MUC1 mucin

MUD mucin, an important protein of epithelial cells and epithelial-derived carcinomas, is also expressed on activated T cells, showing both positive and negative regulatory functions. It is currently unknown whether MUC1 is a true regulatory protein of T cells and what conditions lead to MUC1 co-stimulation versus co-inhibition. We have found that MUD is expressed on the majority of T-regulatory cells (CD4(+)/CD25(+)/FoxP3(+)) in humans (>90%) and that CD3/MUC1 co-stimulation leads to an increased number of T-regulatory cells. We also discovered that the immunoregulatory function is dependent upon the number of accessory (CD3(-)) cells present, with co-inhibition occurring with <5-10% accessory cells while co-stimulation begins with a reconstitution of similar to 50% accessory cells. Co-inhibition was also found to not be the result of the apoptosis but a separate and unknown pathway. This data further characterizes MUC1 as an immunoregulatory protein of T cells capable of giving a positive or negative stimulus.

• 出版日期2012