A novel mixed-ligand antimycobacterial dimeric copper complex of ciprofloxacin and phenanthroline

作者:Saha DK; Sandbhor U; Shirisha K; Padhye S*; Deobagkar D; Anson CE; Powell AK
来源:Bioorganic & Medicinal Chemistry Letters, 2004, 14(12): 3027-3032.
DOI:10.1016/j.bmcl.2004.04.043

摘要

A novel mixed-ligand Cu(II) complex of ciprofloxacin (cfH) and phenanthroline, is found to crystallize as a dimeric moiety containing monocationic and dicationic species. Two such dimeric moieties are found in the same unit cell leading to a dicationic cluster. The higher negative redox potential for this cluster dampens its antimycobacterial activity against M. smegmatis.

  • 出版日期2004-6-21