A gold(I)-catalyzed substituent-controlled cycloisomerization of propargyl vinyl ethers to multi-substituted furofuran and furopyran derivatives

作者：Liu, Yongxiang^*; Jin, Shengfei; Wang, Yanshi; Cui, Shanshan; Peng, Xiaoshi; Niu, Yuanyuan; Du, Chuan; Cheng, Maosheng^*

来源：Chemical Communications, 2016, 52(37): 6233-6236.

DOI：10.1039/c6cc01770c

• GOLD CATALYSIS
• MECHANISTIC INSIGHTS
• REGIOSELECTIVITY
• SWITCH
• CYCLIZATION
• ACTIVATION
• PATHWAY
• BONDS

A gold(I)-catalyzed substituent-controlled strategy for the stereoselective synthesis of bicyclic furan and pyran derivatives has been developed. The mechanisms of the reactions have been studied thoroughly by deuterium labelling experiments. The applications of the methodologies were demonstrated by evaluating the preliminary anti-fungal activity of the synthetic compounds.

• 出版日期2016
• 单位沈阳药科大学