An expedient and green protocol for the Michael addition of malonates, diketones and beta-keto esters to the nitrostyrenes

作者：Agarwal Jyoti; Naganaboina Ram Tilak; Peddinti Rama Krishna^*

来源：Indian Journal of Chemistry - Section B: Organic and Medicinal Chemistry , 2013, 52(4): 511-518.

• Green synthesis
• Michael reaction
• carbon nucleophiles
• grinding
• conjugate addition

A novel methodology has been developed for the rapid synthesis of functionalized nitroalkanes by the addition of less reactive carbon nucleophiles such as malonate esters, acetylacetone and ethyl acetoacetate to various trans-beta-nitrostyrenes under solvent-free conditions. The products are obtained in yields upto 99% within 2-15 minutes by simple mixing of both. the reactants in the presence of triethylamine. In several cases the products are obtained in pure form without subjecting to purification steps such as column chromatography or crystallization.

• 出版日期2013-4