科研之友
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摘要
An efficient route for the synthesis of almazole D has been developed using oxidative cyclization as a key step. This approach is successfully applied to the first synthesis of almazole D enantiomer. (R)-almazole D and synthesized intermediates showed potent inhibition of Mycobacterium tuberculosis. This hybrid 5-(3-indolyl) oxazole scaffold has drug like properties and is a good starting point for further exploration in antituberculosis drug discovery.
- 出版日期2017-1
