Maternal Genotype and Gestational Diabetes

作者：Stuebe Alison M^*; Wise Alison; Thutrang Nguyen; Herring Amy; North Kari E; Siega Riz Anna Maria

来源：American Journal of Perinatology, 2014, 31(1): 68-76.

DOI：10.1055/s-0033-1334451

• diabetes
• gestational diabetes
• genetics
• single nucleotide polymorphisms

ObjectiveTo determine whether genetic variants associated with glucose homeostasis are associated with gestational diabetes (GDM).
Study DesignWe genotyped 899 self-identified Caucasian women and 386 self-identified African-American women in the Pregnancy, Infection and Nutrition (PIN) Studies cohorts for 38 single-nucleotide polymorphisms (SNPs) associated with type II diabetes (T2DM) and/or glucose homeostasis in European populations.
ResultsGDM was diagnosed in 56 of 899 (6.2%) Caucasian and 24 of 386 (6.2%) African-American women. Among Caucasian women, GDM was associated with carriage of TCF7L2 rs7901695, MTNR1B rs10830963 and GCKR rs780094 alleles that are associated with T2DM and fasting glucose in nonpregnant populations. Among African-American participants, we found an increased risk among TSPAN8 rs7961581 C allele homozygotes and reduced risk among carriers of the JAZF1 rs864745 T allele.
ConclusionWe found several SNPs that are associated with GDM risk in the PIN cohorts. Maternal genotyping may identify women at risk for impaired gestational glucose tolerance.

• 出版日期2014-1