Utility of Brain Natriuretic Peptide in Diagnosis of Congestive Heart Failure and Comparison with Trans-Thoracic Echocardiography: A Multicenter Analysis in South Asian and Arabian Population

作者：Ejaz Nauman^*; Khalid M Rizwan

来源：Journal of the College of Physicians and Surgeons Pakistan, 2015, 25(1): 12-15.

• B-type Natriuretic Peptide (BNP)
• Ejection Fraction (EF)
• Congestive Heart Failure (CHF)
• Echocardiography

Objective: To evaluate serum Brain Natriuretic Peptide levels (BNP) as a screening test in the diagnosis of congestive heart failure.
Study Design: Comparative cross-sectional study.
Place and Duration of Study: Prince Salman Heart Center, King Fahad Medical City, Riyadh, Saudi Arabia between December 2010 to January 2012 and Nishtar Hospital, Mu [tan, Pakistan, from February to August 2006.
Methodology: A total of 80 patients with clinical diagnosis of Congestive Heart Failure (CHF) underwent measurement of serum BNP and had a trans-thoracic echocardiography to measure Ejection Fraction (EF). The normal limit for serum BNP levels, provided by the manufacturer of the kit was applied as a cut-off value for BNP. EF of > 45% was considered normal.
Results: Forty seven patients (94%) had an EF <45%. BNP levels were elevated in 36 patients (72%). Sensitivity and specificity of BNP was found to be 80% and 66% respectively and accuracy was 80%.
Conclusion: BNP measurements as a screening tool for CHF has good sensitivity and accuracy when compared to echocardiography.

• 出版日期2015-1