科研之友
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摘要
Intramolecular dehydrogenative cyclization of aliphatic amides was achieved on unactivated sp(3) carbon atoms by a nickel-catalyzed C-H bond functionalization process with the assistance of a bidentate directing group. The reaction favors the C-H bonds of b-methyl groups over the gamma-methyl or beta-methylene groups. Additionally, a predominant preference for the beta-methyl C-H bonds over the aromatic sp(2) C-H bonds was observed. Moreover, this process also allows for the effective functionalization of benzylic secondary sp(3) C-H bonds.
- 出版日期2014-7-28
- 单位南京大学
