Health-related quality of life in patients with chronic obstructive pulmonary disease in North India

作者：Negi H^*; Sarkar M; Raval A D; Pandey K; Das P

来源：Journal of Postgraduate Medicine, 2014, 60(1): 7-11.

DOI：10.4103/0022-3859.128797

• Chronic obstructive pulmonary disease
• Global Initiative for Chronic Obstructive Lung Disease
• health-related quality of life
• India
• tertiary care

Background and Objectives: Chronic obstructive pulmonary disease (COPD) is a major health problem in India and constitutes an important cause of mortality and morbidity. A cross-sectional study was undertaken to assess health-related quality of life (HRQL) and its determinants in patients with COPD from India. Materials and Methods: A total of 126 patients (73.81% male) were enrolled using convenient sampling prospectively in this cross-sectional study. Eligible patients were assessed for socioeconomic status, anthropometric measures, COPD severity, dyspnea and health status using the Hindi version of St George%26apos;s Respiratory Questionnaire (SGRQ). Linear regression model was used to examine the association between risk factors and HRQL score (a higher score indicating poorer HRQL), adjusting for age and sex. Results: The mean total score for SGRQ in the patients was 52.66 +/- 12.89, indicating a marked impairment of HRQL. Impairment was associated with the severity of airway obstruction, but within each Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage, the variation (SD) was wide [stage I: 47.8 +/- 12.3 (n = 14); stage II: 49.28 +/- 11.69 (n = 47); stage III: 53.47 +/- 11.69 (n = 44); stage IV: 61.75 +/- 14.14 (n = 21)]. A regression analysis showed that body mass index, forced expiratory volume in 1 s (FEV1), dyspnea grade, and depression were associated with poor HRQL. Conclusion: HRQL of COPD patients was significantly impaired across stages. Marked impairment of HRQL was found even in patients with mild disease.

• 出版日期2014-3
• 单位河北医科大学