An electrochemical dopamine sensor with a CMOS detection circuit

作者：Chan Feng Lin; Chang Wen Ying; Kuo Li Min; Lin Chih Heng; Wang Shi Wei; Yang Yuh Shyong; Lu Michael S C

来源：Journal of Micromechanics and Microengineering, 2008, 18(7): 075028.

DOI：10.1088/0960-1317/18/7/075028

This paper presents the integration of interdigitated microelectrodes and a CMOS circuit for electrochemical sensing of the neurotransmitter dopamine. Gold electrodes with a gap of 3 mu m are fabricated by the lift-off technique. The CMOS sensing circuit has a current gain of 10, an integrating capacitor of 4 pF, and a measured dynamic range of 60 dB. The applied reduction and oxidation potentials are determined by voltammetry at about -0.2 V and 0.6 V, respectively. The measured collection efficiency can reach up to 84%. The produced oxidation current with respect to dopamine concentration averages 0.44 nA mu M(-1).

• 出版日期2008-7
• 单位清华大学; 中国科学院电工研究所