Activating mutation of PDGFRB gene in a rare cardiac undifferentiated intimal sarcoma of the left atrium: a case report

作者：Fu, Xiaoling; Niu, Weixin; Li, Ji; Kiliti, Amber J.; Al-Ahmadie, Hikmat A.; Iyer, Gopa; Gao, Sizhi Paul^*; Li, Qi^*

来源：Oncotarget, 2017, 8(46): 81709-81716.

DOI：10.18632/oncotarget.20700

• cardiac sarcoma
• intimal sarcoma
• memorial sloan kettering-integrated mutation profiling of actionable cancer targets
• PDGFRA
• PDGFRB

Cardiac sarcoma is a rare malignant tumor with undefined genetic mutations and no targeted therapy. Here in one rare case of undifferentiated cardiac intimal sarcoma (IS), a next-generation sequencing based assay, MSK-IMPACT (Memorial Sloan Kettering - Integrated Mutation Profiling of Actionable Cancer Targets), identified a somatic, activating mutation in PDGFRB, along with amplification of PDGFRA. This E472D mutation of PDGFRB was discovered for the first time in IS. These findings suggest that concurrent aberrant PDGFRA and PDGFRB signaling may be a diagnostic biomarker and molecular therapeutic target of IS of the heart.

• 出版日期2017-10-6
• 单位复旦大学; 上海中医药大学