Amelioration of D-Galactosamine-Induced Acute Liver Injury in Rats by Dietary Supplementation with Betaine Derived from Sugar Beet Molasses

作者：Okada Tomoko; Kawakami Sakura; Nakamura Yumi; Han Kyu Ho; Ohba Kiyoshi; Aritsuka Tsutomu; Uchino Hirokatsu; Shimada Ken ichiro; Sekikawa Mitsuo; Ishii Hiroshi; Fukushima Michihiro^*

来源：Bioscience Biotechnology and Biochemistry, 2011, 75(7): 1335-1341.

DOI：10.1271/bbb.110105

• betaine
• D-galactosamine
• glutathione
• S-adenosyl methionine

The effects of betaine supplementation on D-galactosamine-induced liver injury were examined in terms of hepatic and serum enzyme activities and of the levels of glutathione and betaine-derived intermediates. The rats induced with liver injury showed marked increases in serum enzyme activity, but those receiving dietary supplementation of 1% betaine showed enzyme activity levels similar to a control group without liver injury. Administration of betaine also increased both hepatic and serum glutathione levels, even following D-galactosamine injection. The activity of glutathione-related enzymes was markedly decreased following injection of D-galactosamine, but remained comparable to that of the control group in rats receiving 1% betaine. The concentrations of hepatic S-adenosyl methionine and cysteine showed similar trends to that observed for hepatic glutathione levels. These results indicate that 1% betaine has a hepatoprotective effect by increasing hepatic and serum glutathione levels along with glutathione-related enzyme activities in rats.

• 出版日期2011-7