Anti-allergic effect of a chloroform-soluble extract of Cinnamomum cambodianum in bone marrow-derived mast cells

作者：Chae Hee Sung; Khiev Piseth; Lee Hyeong Kyu; Oh Sei Ryang; Chin Young Won^*

来源：Immunopharmacology and Immunotoxicology, 2012, 34(4): 639-644.

DOI：10.3109/08923973.2011.648267

• Cinnamomum cambodianum
• interleukin-6
• prostaglandin D-2
• leukotriene C-4
• degranulation
• bone marrow-derived mast cell

Cinnamomum cambodianum has been used as a traditional medicine in Cambodia. Its effect on the bone marrow-derived mast cells (BMMCs) mediated allergic response remains unknown. In this study, a chloroform-soluble extract of C. cambodianum was evaluated for its effect on allergic mediators, including prostaglandin D-2 (PGD(2)), leukotriene C-4 (LTC4), beta-hexosaminidase and cyclooxygenase-2 (COX-2) protein, in phorbol 12-myristate 13-acetate (PMA) plus calcimycin-stimulated BMMCs. The results revealed that the chloroform-soluble extract inhibited the production of interleukin-6, PGD(2) and LTC4, and the expression of COX-2 in PMA plus calcimycin-stimulated BMMCs, implying a potential benefit of C. cambodianum in the treatment of allergy.

• 出版日期2012-8