Application of L-cysteine capped core-shell CdTe/ZnS nanoparticles as a fluorescence probe for cephalexin

作者：Li, Li; Zhang, Qiaolin; Ding, Yaping^*; Cai, Xiaoyong; Gu, Shuqing; Cao, Zhiyuan

来源：Analytical Methods, 2014, 6(8): 2715-2721.

DOI：10.1039/c4ay00094c

• LIQUID-CHROMATOGRAPHIC METHOD
• CDS QUANTUM DOTS
• IMMUNOANALYSIS SYSTEM
• ZNS NANOPARTICLES
• HUMAN PLASMA
• CEFALEXIN
• PHOTOLUMINESCENCE
• SERUM
• IONS
• MILK

In this paper, a novel method was developed for rapid and quantitative determination of cephalexin on the basis of the fluorescence quenching of L-cysteine capped core-shell CdTe/ZnS nanoparticles (NPs). The functionalized CdTe/ZnS NPs were successfully synthesized in aqueous solution. L-Cysteine capped CdTe/ZnS NPs were characterized by the means of X-ray diffraction (XRD), transmission electron microscopy (TEM) and Fourier transform infrared (FTIR) spectroscopy. Experimental results displayed that the fluorescence intensity of CdTe/ZnS NPs reduced in the presence of cephalexin due to interaction between L-cysteine capped CdTe/ZnS NPs and cephalexin, with the emission wavelength at about 665 nm. Under optimal conditions, the relative fluorescence intensity was linearly proportional to the concentration of cephalexin ranging from 3.4 x 10(-6) to 1.0 x 10(-4) M with a detection limit of 0.83 x 10(-6) M. The L-cysteine capped CdTe/ZnS NPs fluorescence probe showed an obvious and good response to cephalexin, and the result was also satisfactory when it was applied to analyzing cephalexin in a real sample.

• 出版日期2014
• 单位上海大学