A combination of soy isoflavones and cello-oligosaccharides changes equol/O-desmethylangolensin production ratio and attenuates bone fragility in ovariectomized mice

作者：Fujii Shungo; Takahashi Nobuyuki; Inoue Hirofumi; Katsumata Shin ichi; Kikkawa Yuji; Machida Makoto; Ishimi Yoshiko; Uehara Mariko^*

来源：Bioscience Biotechnology and Biochemistry, 2016, 80(8): 1632-1635.

DOI：10.1080/09168451.2016.1184559

• isoflavones
• cello-oligosaccharides
• equol
• O-desmethylangolensin
• osteoporosis

We examined the cooperative effects of isoflavones and cello-oligosaccharides on daidzein metabolism and bone fragility in ovariectomized mice. Cello-oligosaccharides increased urinary equol and decreased O-desmethylangolensin. A combination of isoflavones and cello-oligosaccharides attenuated decreases in bone breaking force and stiffness caused by ovariectomy. Combination treatment with isofalvones and cello-oligosaccharides increases urinary equol/O-desmethylangolensin production ratio and prevents ovariectomy-induced abnormalities in bone strength.

• 出版日期2016-8