Antidepressant Abietane Diterpenoids from Chinese Eaglewood

作者：Yang, Lin; Qiao, Lirui; Ji, Chengxue; Xie, Dan; Gong, Ning-Bo; Lu, Yang; Zhang, Jianjun; Dai, Jungui^*; Guo, Shunxing

来源：Journal of Natural Products, 2013, 76(2): 216-222.

DOI：10.1021/np3006925

• PINUS-MASSONIANA RESIN
• AQUILARIA-AGALLOCHA
• AGARWOOD
• 2-(2-PHENYLETHYL)CHROMONES
• CONSTITUENTS
• SESQUITERPENE
• DERIVATIVES
• AGAROSPIROL
• TERPENOIDS
• SINENSIS

Ten new abietane diterpenoids, aquilarabietic acids A-J (1-10), and a new podocarpane diterpenoid, aquilarabietic acid K (11), were isolated from the petroleum ether and ethanol extracts of Chinese eaglewood. Among them, 3, 9, and 10 are artifacts. Their structures were established on the basis of data from extensive spectroscopic and X-ray diffraction analyses. Bioassay results indicated that 1 at 10 mu M demonstrated remarkable antidepressant activity in vitro by inhibiting norepinephrine reuptake in rat brain synaptosomes by 81.4% and with an IC50 value of 9.1 x 10(-7) M.

• 出版日期2013-2
• 单位中央民族大学; 中国医学科学院北京协和医院; 北京协和医学院; 天然药物活性物质与功能国家重点实验室; 河北医科大学