All-Cause Mortality and Medication Risk Factors in Schizophrenia A Prospective Cohort Study

作者：Tenback Diederik^*; Pijl Bram; Smeets Hugo; van Os Jim; van Harten Peter

来源：Journal of Clinical Psychopharmacology, 2012, 32(1): 31-35.

DOI：10.1097/JCP.0b013e31823f3c43

• schizophrenia
• mortality
• epidemiology
• clinical pharmacology
• cohort studies

Background: It is well established that persons with schizophrenia have high mortality rates. There is conflicting evidence that antipsychotic and perhaps other medications routinely used to treat schizophrenia contribute to mortality risk. %26lt;br%26gt;Methods: A health insurer database was used to examine schizophrenia diagnosis and mortality in 2008. Information from the period 2006-2008 was used to analyze demographics and medication prescriptions. The risk set composed of patients with schizophrenia using an antipsychotic (n = 7415) and a group of randomly chosen control subjects (n = 97,726). %26lt;br%26gt;Results: The mortality risk for having a diagnosis of schizophrenia and using an antipsychotic versus the random control group was a hazard ratio (HR) of 2.6; 95% CI, 2.0-3.2. Over the 3-year period, age, receiving a first-generation antipsychotic, and the use of a mood stabilizer were associated with a higher risk of mortality: HR, 1.06; 95% CI, 1.04-1.08; HR, 2.36; 95% CI, 1.38-4.04; and HR, 8.42; 95% CI, 3.06-24.07, respectively. %26lt;br%26gt;Conclusion: Patients with schizophrenia have higher mortality rates than normal controls. The type of antipsychotic and concomitant medication can affect mortality rates in schizophrenia.

• 出版日期2012-2