Antiangiogenic-targeting drug-loaded microbubbles combined with focused ultrasound for glioma treatment

作者：Fan Ching Hsiang; Ting Chien Yu; Liu Hao Li; Huang Chiung Yin; Hsieh Han Yi; Yen Tzu Chen; Wei Kuo Chen; Yeh Chih Kuang^*

来源：Biomaterials, 2013, 34(8): 2142-2155.

DOI：10.1016/j.biomaterials.2012.11.048

• Targeting microbubble
• Focused ultrasound (FUS)
• Glioblastoma multiforme (GBM)
• Chemotherapy
• Blood-brain barrier (BBB)
• Antiangiogenic therapy

Current chemotherapeutic agents do not only kill tumor cells but also induce systemic toxicity that significantly limits their dosage. Focused ultrasound (FUS) in the presence of microbubbles (MBs) is capable of transient and local opening of the blood brain barrier (BBB) that enhances chemotherapeutic drug delivery into the brain parenchyma for glioma treatment. Our previous results demonstrated the success of combining the use of drug (1,3-bis(2-chloroethyl)-1-nitrosourea, BCNU)-loaded MBs with FUS-induced BBB opening to improve local drug delivery and reduce systemic toxicity. Here we introduce novel VEGF-targeting, drug-loaded MBs that significantly further enhance targeted drug release and reduce tumor progression in a rat model, using the FUS-BBB opening strategy. This study suggests a promising direction for future MB design aimed at targeted brain tumor therapy, and the possible future extension of MB application towards theragnostic use.

• 出版日期2013-3
• 单位长春大学; 清华大学