SNCA Variants Are Associated with Increased Risk for Multiple System Atrophy

作者：Scholz Sonja W^*; Houlden Henry; Schulte Claudia; Sharma Manu; Li Abi; Berg Daniela; Melchers Anna; Paudel Reema; Gibbs J Raphael; Simon Sanchez Javier; Paisan Ruiz Coro; Bras Jose; Ding Jinhui; Chen Honglei; Traynor Bryan J; Arepalli Sampath; Zonozi Ryan R; Revesz Tamas; Holton Janice; Wood Nick; Lees Andrew; Oertel Wolfgang; Wuellner Ullrich; Goldwurm Stefano; Pellecchia Maria Teresa; Illig Thomas; Riess Olaf; Fernandez Hubert H; Rodriguez Ramon L

来源：Annals of Neurology, 2009, 65(5): 610-614.

DOI：10.1002/ana.21685

<jats:title>Abstract</jats:title><jats:p>To test whether the synucleinopathies Parkinson's disease and multiple system atrophy (MSA) share a common genetic etiology, we performed a candidate single nucleotide polymorphism (SNP) association study of the 384 most associated SNPs in a genome‐wide association study of Parkinson's disease in 413 MSA cases and 3,974 control subjects. The 10 most significant SNPs were then replicated in additional 108 MSA cases and 537 controls. SNPs at the <jats:italic>SNCA</jats:italic> locus were significantly associated with risk for increased risk for the development of MSA (combined <jats:italic>p</jats:italic> = 5.5 × 10<jats:sup>12</jats:sup>; odds ratio 6.2). Ann Neurol 2009;65:610–614</jats:p>

• 出版日期2009-5