A Novel Selective Coated-Wire Potentiometric Sensor for Venlafaxine Determination in Pharmaceutical Compounds, Plasma and Urine

作者：Ensafi Ali A^*; Faridfar R; Allafchian Ali R

来源：Sensor Letters, 2011, 9(2): 479-484.

DOI：10.1166/sl.2011.1501

• Potentiometric Sensor
• Venlafaxine Determination
• Sodium Tetraphenyl Phthalate

The construction and electrochemical response characteristics of polyvinyl chloride (PVC) membrane sensor for the determination of venlafaxine is described. The sensor having venlafaxine-sodium tetraphenyl borate (ion-pair) as an electroactive material and dibutyl phthalate (DBP) as a plasticizer in a PVC matrix in the percentage ratio of 5.1:66.0:28.9 (ion-pair:DBP:PVC, w/w). The sensor exhibits a linear response to venlafaxine in a concentration range of 1.0 x 10(-2) to 8.0 x 10(-6) mol L(-1) with a limit of detection of 5.0 x 10(-6) mol L(-1) and with a slope of 29.4 +/- 0.1 mV decade(-1) over the pH range 3.0-9.0. Selectivity coefficients of the sensor for venlafaxine relative to a numbers of potential interfering substances were investigated. The sensor is highly selective for venlafaxine over a large number of similar compounds. The sensor showing a fast response time of 10 s and was used over a period of 2 months (for two determinations every day) with a good reproducibility. The sensor was successfully applied to determine venlafaxine in pharmaceutical, urine and blood serum samples with satisfactory results.

• 出版日期2011-4