New method for the synthesis of 2-hetaryl-2-(1-R-pyrrolidin-2-ylidene)acetonitriles

作者：Kuleshova Olena A^*; Khilya Olga V; Volovenko Yulian M

来源：Chemistry of Heterocyclic Compounds, 2018, 54(1): 83-85.

DOI：10.1007/s10593-018-2234-x

• hetarylacetonitriles
• 2-hetaryl-2-(1-R-pyrrolidin-2-ylidene)acetonitriles
• pyrrolinium salts
• condensation reactions
• three-component reaction

New method was developed for the synthesis of 2-hetaryl-2-(1-R-pyrrolidin-2-ylidene)acetonitriles by using a three-component condensation of hetarylacetonitrile, phosphorus oxychloride, and 1-R-pyrrolidin-2-one. This method is applicable to the synthesis of beta-enaminonitriles containing azoles and six-membered azaheteroaromatic rings at the alpha-position relative to the nitrile group.

• 出版日期2018-1