Aryl-1H-imidazole[4,5f] [1,10]phenanthroline Cu(II) complexes: Electrochemical and DNA interaction studies

作者：Rajebhosale Bharati S; Dongre Shivali N; Deshpande Sameer S; Kate Anup N; Kumbhar Anupa A^*

来源：Journal of Inorganic Biochemistry, 2017, 175: 129-137.

DOI：10.1016/j.jinorgbio.2017.07.008

• DNA binding
• Molecular docking
• DNA cleavage

The reaction of aryl imidazo[4,5f] [1,10]phenanthrolines with Cu(NO3)(2) lead to the formation of Cu(II) complexes of the type [Cu(L)(NO3)(2)] where L = PIP, 2-(phenyl) [4,5f] imidazo phenanthroline; HPIP = 2-(2-hydroxyphenyl)imidazo [4,5f] phenanthroline and NIP = 2-(naphthyl) [4,5f] imidazo phenanthroline. The interaction of these complexes with calf thymus DNA has been studied using viscosity measurements, UV-visible and fluorescence spectroscopy. Chemical nuclease activity of these complexes has also been investigated. All complexes cleave DNA via oxidative pathway involving singlet oxygen. Molecular docking studies revealed that these complexes bind to DNA through minor groove.

• 出版日期2017-10