A novel group of rhinoviruses is associated with asthma hospitalizations

作者：Miller E Kathryn^*; Edwards Kathryn M; Weinberg Geoffrey A; Lwane Marika K; Griffin Marie R; Hall Caroline B; Zhu Yuwei; Szilagyi Peter G; Morin Laura Lee; Heil Luke H; Lu Xiaoyan; Williams John V

来源：Journal of Allergy and Clinical Immunology, 2009, 123(1): 98-104.

DOI：10.1016/j.jaci.2008.10.007

• Human rhinoviruses
• asthma
• children
• wheezing
• hospitalized
• genetic diversity

Background: Although recent studies have identified new group C human rhinoviruses (HRVCs), their spectrum of pediatric disease is unknown.
Objective: We sought to determine the presentation and burden of disease caused by HRVCs among young hospitalized children.
Methods: We conducted prospective population-based surveillance in 2 US counties among children less than 5 years of age hospitalized with acute respiratory illness or fever from October 2001 through September 2003. Nasal/throat swabs were obtained and tested for HRVs, as determined by means of RT-PCR and then characterized by means of partial sequencing.
Results: Of 1052 children enrolled and tested during the 2-year period, 167 (16%) had HRVs detected. Of 147 samples successfully sequenced, 64 were group A HRVs, 6 were group B HRVs, and 77 were HRVCs. Children with HRVCs were significantly more likely than those with group A HRVs to have underlying high-risk conditions, such as asthma (42% vs 23%, P = .023) and to have had a discharge diagnosis of asthma (55% vs 36%, P = .022).
Conclusions: Overall, HRVCs were detected in 7% of children hospitalized for fever or respiratory conditions and constituted almost half of all rhinovirus-associated hospitalizations, suggesting that this novel group causes a substantial burden of pediatric disease. (J Allergy Clin Immunol 2009;123:98-104.)

• 出版日期2009-1