Antioxidant, antitumor and immunomodulatory activities of water-soluble polysaccharides in Abrus cantoniensis

作者：Wu, Shaowei; Fu, Xiong; You, Lijun; Abbasi, Arshad Mehmood; Meng, Hecheng^*; Liu, Dong^*; Aadil, Rana Muhammad

来源：International Journal of Biological Macromolecules, 2016, 89: 707-716.

DOI：10.1016/j.ijbiomac.2016.04.005

• Polysaccharides
• Abrus cantoniensis
• Antitumor
• Immunomodulatory

Abrus cantoniensis is a vegetative food in tropical areas of Asia and claimed as folk beverages and soups consumed for cleansing liver toxicants and preventing liver diseases. Polysaccharides (ACP-I and ACP-II) were extracted with hot water from A. cantoniensis, and isolated by DEAE cellulose chromatography. The chemical properties as well as antioxidant, antitumor and immunomodulatory activities of ACP-I and ACP-II were investigated. The results showed that the ACP-I (9.09 kDa) contained only glucose and ACP-II (38.45 kDa) consisted of rhamnose, arabinose, galactose and glucose. ACP-II exhibited higher oxygen radical absorbance capacity (ORAC) and hydroxyl radical prevention capacity (HRPC) than ACP-I with ORAC values and HRPC values of 53.42 +/- 3.32 mu mol Trolox equiv./g DW and 34.84 +/- 5.07 mu mol Trolox equiv./g DW. Besides, in the wound healing assay, ACP-II exhibited potent migration inhibitory effects on MCF-7 cells. ACP-II could also significantly stimulate the proliferation of splenocytes and thymocytes, and enhanced NO production of peritoneal macrophages. These findings suggest that the polysaccharide ACP-II in A. cantoniensis could be served as a novel potential functional food.

• 出版日期2016-8
• 单位华南理工大学; 深圳职业技术学院