Muscle density predicts changes in bone density and strength: a prospective study in girls

作者：Laddu D R^*; Farr J N; Lee V R; Blew R M; Stump C; Houtkooper L; Lohman T G; Going S B

来源：The Journal of Musculoskeletal and Neuronal Interactions, 2014, 14(2): 195-204.

• Skeletal Muscle Fat Content
• Bone Development
• Girls
• volumetric Bone Mineral Density (vBMD)
• peripheral Quantitative Computed Tomography (pQCT)

Objective: We sought to determine whether muscle density, an index of skeletal muscle fat content, was predictive of 2-year changes in weight-bearing bone parameters in young girls. Methods: Two-year prospective data from 248 girls, aged 8-13 years at baseline. Peripheral quantitative computed tomography was used to measure changes in bone strength indices (bone strength index [BSI, mg(2)/mm(4)] and strength-strain index [SSIp, mm(3)]) and volumetric bone mineral density [vBMD, mg/cm(3)] at distal metaphyseal and diaphyseal regions of the femur and tibia, as well as calf and thigh muscle density (mg/cm(3)), and muscle cross-sectional area (MCSA, mm(2)), indices of skeletal muscle fat content and muscle force production, respectively. Results: After controlling for potential confounders, greater gains in femur BSI (44%, P<0.002), total femur vBMD (114%, P<0.04) and femur trabecular vBMD (306%, P<0.002) occurred in girls in the lowest versus the highest groups of baseline thigh muscle density. Greater gains in tibial BSI (25%, P<0.03) and trabecular vBMD (190%, P<0.002) were also observed in the lowest versus the highest baseline calf muscle density groups. Conclusion: Baseline muscle density is a significant predictor of changes in bone density and bone strength in young girls during a period of rapid skeletal development. NIH/NICHD #HD-050775.

• 出版日期2014-6