Methylenecyclopropane Ring Formation/Opening Cascade for the Synthesis of Indolizines

作者:Zhu, Congjun; Zhao, Peng; Qiao, Yan; Xiao, Ke; Song, Chuanjun*; Chang, Junbiao*
来源:Journal of Organic Chemistry, 2017, 82(13): 7045-7049.
DOI:10.1021/acs.joc.7b01073

摘要

A unique strategy toward the synthesis of polysubstituted indolizines has been developed. When 2-pyridinyl-2-(2'-bromoallyl)-1-carboxylates were treated with Cs2CO3, the starting material went through a methylenecyclopropane ring formation/opening cascade, and the corresponding indolizines were obtained in moderate to good yield as a single regioisomer.