A novel form of capsaicin-modified amygdala LTD mediated by TRPM1

作者：Gebhardt Christine; von Bohlen und Halbach Oliver; Hadler Michael D; Harteneck Christian; Albrecht Doris^*

来源：Neurobiology of Learning and Memory, 2016, 136: 1-12.

DOI：10.1016/j.nlm.2016.09.005

• Mice
• Lateral nucleus of the amygdala
• Long-term depression
• Capsaicin
• TRPM1
• TRPC5
• Immunohistochemistry

Recently we have shown that capsaicin attenuates the strength of LTP in the lateral amygdala (LA) and demonstrated that this effect is mediated by the transient receptor potential (TRP) channel TRPV1. Here we further show that capsaicin, which is thought to act primarily through TRPV1, modifies long term depression (LTD) in the LA. Yet the application of various TRPV1 antagonists does not reverse this effect and it remains in TRPV1-deficient mice. In addition, voltage gated calcium channels, nitric oxide and CB1 receptors are not involved. Using pharmacology and TRPM1(-/-) mice, our electrophysiological data indicate that capsaicin-induced activation of TRPMI channels contribute to the induction of LA LTD. Whereas LA-LTD in general depends on the acitvation of NMDA receptors-and group II metabotropic glutamate receptors (mGluR), the modifying effect of Capsaicin on LA-LTD via TRPMI appears to be specifically mediated by group I mGluRs and in interaction with another member of the TRP family, TRPC5. Additionally, intact GABAergic transmission is required for the capsaicin-effect to take place. This is the first documentation that beside their function in the retina TRPMI proteins are expressed in the brain and have a functional relevance in modifying synaptic plasticity.

• 出版日期2016-12