A Perspective on the Structure and Receptor Binding Properties of Immunoglobulin G Fc

作者：Hanson Quinlin M; Barb Adam W^*

来源：Biochemistry, 2015, 54(19): 2931-2942.

DOI：10.1021/acs.biochem.5b00299

Recombinant antibodies spurred a revolution in medicine that saw the introduction of powerful therapeutics for treating a wide range of diseases, from canters to autoimmune disorders and transplant rejection, with more applications looming on the horizon. Many of these therapeutic monoclonal antibodies (mAbs) are based on human immunoglobulin G1 (IgG1) or contain at least a portion of the molecule. Most mAbs require interactions with cell surface receptors for efficacy, including the Fc gamma receptors. High-resolution structural models of antibodies and antibody fragments have been available for nearly 40 years; however, a thorough description of the structural features that determine the affinity with which antibodies interact with human receptors has not been published. In this review, we will cover the relevant history of IgG-related literature and how recent developments have changed our view of critical antibody cell interactions at the atomic level with a nod to outstanding questions in the field and future prospects.

• 出版日期2015-5-19