A Histone Methylation Network Regulates Transgenerational Epigenetic Memory in C-elegans

作者:Greer Eric L; Beese Sims Sara E; Brookes Emily; Spadafora Ruggero; Zhu Yun; Rothbart Scott B; Aristizabal Corrales David; Chen Shuzhen; Badeaux Aimee I; Jin Qiuye; Wang Wei; Strahl Brian D; Colaiacovo Monica P; Shi Yang*
来源:Cell Reports, 2014, 7(1): 113-126.
DOI:10.1016/j.celrep.2014.02.044

摘要

How epigenetic information is transmitted from generation to generation remains largely unknown. Deletion of the C. elegans histone H3 lysine 4 dimethyl (H3K4me2) demethylase spr-5 leads to inherited accumulation of the euchromatic H3K4me2 mark and progressive decline in fertility. Here, we identified multiple chromatin-modifying factors, including H3K4me1/me2 and H3K9me3 methyltransferases, an H3K9me3 demethylase, and an H3K9me reader, which either suppress or accelerate the progressive transgenerational phenotypes of spr-5 mutant worms. Our findings uncover a network of chromatin regulators that control the transgenerational flow of epigenetic information and suggest that the balance between euchromatic H3K4 and heterochromatic H3K9 methylation regulates transgenerational effects on fertility.

  • 出版日期2014-4