The Role of Radiotherapy in Endometrial Cancer: Current Evidence and Trends

作者：Creutzberg Carien L^*; Nout Remi A

来源：Current Oncology Reports, 2011, 13(6): 472-478.

DOI：10.1007/s11912-011-0191-y

• Endometrial cancer
• Adjuvant therapy
• Radiation therapy
• Prognostic factors
• Side effects
• Quality of life

Adjuvant treatment of patients with endometrial cancer is tailored to clinical-pathological prognostic factors. Pelvic radiation therapy for stage I endometrial cancer (EC) provides a highly significant improvement of local control, but without survival advantage. Low-risk EC patients have a very favorable prognosis, and should be observed after surgery. Use of adjuvant radiotherapy (RT) is limited to patients with high-intermediate or high-risk factors. For those with high-intermediate risk features, vaginal brachytherapy alone provides excellent vaginal control with less morbidity and better quality of life than pelvic external beam RT (EBRT). For patients with stage I-III EC with high-risk features, the use of adjuvant chemotherapy alone has not shown survival benefit as compared to pelvic EBRT. A first trial comparing pelvic EBRT with or without adjuvant chemotherapy has shown better progression-free survival with combined therapy. Current ongoing trials are exploring the role of combined RT and chemotherapy, compared to chemotherapy or RT alone.

• 出版日期2011-12