Detection of Bone Metastases in Non-Small Cell Lung Cancer Patients: Comparison of Whole-Body Diffusion-Weighted Imaging (DWI), Whole-Body MR Imaging Without and With DWI, Whole-Body FDG-PET/CT, and Bone Scintigraphy

作者：Takenaka Daisuke; Ohno Yoshiharu^*; Matsumoto Keiko; Aoyama Nobukazu; Onishi Yumiko; Koyama Hisanobu; Nogami Munenobu; Yoshikawa Takeshi; Matsumoto Sumiaki; Sugimura Kazuro

来源：Journal of Magnetic Resonance Imaging, 2009, 30(2): 298-308.

DOI：10.1002/jmri.21858

• MRI
• nuclear medicine
• lung cancer
• bone metastasis
• PET/CT
• SPECT

Purpose: To prospectively compare the capability for bone metastasis assessment of whole-body diffusion-weighted imaging (DWI), magnetic resonance imaging (MRI) without and with DWI, [(18)F] fluoro-2-D-glucose positron emission tomography with computed tomography (FDG-PET/CT) and bone scintigraphy in non-small cell carcinoma (NSCLC) patients.
Materials and Methods: In all, 115 consecutive NSCLC patients (66 men, 49 women; mean age 72 years) prospectively underwent whole-body MRI, PET/CT, and bone scintigraphy before treatment. For each method, probability of metastasis was independently assessed by using a 5-point visual scoring system on a per-site basis. Receiver operating characteristic (ROC)-based positive tests were used to determine the practical threshold value for each method on a per-site basis. Sensitivities, specificities, and accuracies were then compared on a per-site and per-patient basis by means of McNemar's test.
Results: When the practical threshold values were adapted, specificity and accuracy of whole-body MRI with DWI were significantly higher than those of bone scintigraphy and PET/CT (P < 0.05). On a per-patient basis, specificity and accuracy of whole-body MRI with DWI were significantly higher than those of bone scintigraphy (P < 0.05).
Conclusion: Whole-body MRI with DWI can be used for bone metastasis assessment of NSCLC patients as accurate as bone scintigraphy and/or PET/CT.

• 出版日期2009-8