Analgesic efficacy of oral firocoxib in ovariohysterectomized cats

作者：Phuwapattanachart Prangtip; Thengchaisri Naris^*

来源：Journal of Veterinary Science, 2017, 18(2): 175-182.

DOI：10.4142/jvs.2017.18.2.175

• analgesia
• cats
• cyclooxygenase
• firocoxib
• ovariohysterectomy

The postoperative analgesic effects of firocoxib in ovariohysterectomized cats were observed. Twenty-four cats were divided into 3 groups: control (no medicine), firocoxib-1 (1 mg/kg/day) and firocoxib-3 (3 mg/kg/day). Colorado pain scale scores (CPSS), composite pain scores (CPS), and buccal mucosal bleeding times (BMBT) were recorded in blinded fashion before induction and 2, 5, 8, 24, 30, and 48 h post-operation. The average CPSS (mean +/- SEM) over 2 to 48 h post-operation in firocoxib-3 (0.4 +/- 0.1) was significantly lower than that of the control (0.7 +/- 0.2; p = 0.004), but that of firocoxib-1 (0.5 +/- 0.2) was not different from that of the control (p = 0.40). The mean CPS of firocoxib-3 was significantly lower than that of the control at 24 h post-operation (p = 0.04); nonetheless, there was no significant difference in mean CPS between firocoxib-1 and control groups at all intervals. BMBT and body temperature were within normal limits in all groups. However, reversible azotemia was identified in two firocoxib-3 cats at 72 h post-operation. One firocoxib-3 cat vomited once at 48 h post-operation. In conclusion, firocoxib-3 is helpful for postoperative pain control in cats; however, gastrointestinal irritation and renal function side effects may occur.

• 出版日期2017