Atrophy of submandibular gland by the duct ligation and a blockade of SP receptor in rats

作者：Hishida Sumiyo; Ozaki Noriyuki; Honda Takashi; Shigetomi Toshio; Ueda Minoru; Hibi Hideharu; Sugiura Yasuo^*

来源：Nagoya Journal of Medical Science, 2016, 78(2): 215-227.

• duct ligation
• atrophy
• nerve fiber
• submandibular gland
• substance P receptor

To clarify the mechanisms underlying the submandibular gland atrophies associated with ptyalolithiasis, morphological changes were examined in the rat submandibular gland following either surgical intervention of the duct or functional blockade at substance P receptors (SPRs). Progressive acinar atrophy was observed after duct ligation or avulsion of periductal tissues. This suggested that damage to periductal tissue involving nerve fibers might contribute to ligation-associated acinar atrophy. Immunohistochemically labeled-substance P positive nerve fibers (SPFs) coursed in parallel with the main duct and were distributed around the interlobular, striated, granular and intercalated duct, and glandular acini. Strong SPR immunoreactivity was observed in the duct. Injection into the submandibular gland of a SPR antagonist induced marked acinar atrophy. The results revealed that disturbance of SPFs and SPRs might be involved in the atrophy of the submandibular gland associated with ptyalolithiasis.

• 出版日期2016-5
• 单位河北医科大学