A novel nanogel delivery of poly-α, β-polyasparthydrazide by reverse microemulsion and its redox-responsive release of 5-Fluorouridine

作者：Guo, Jingwen; Wang, Yan; Wang, Jing; Zheng, Xin; Chang, Di; Wang, Siling; Jiang, Tongying^*

来源：Asian Journal of Pharmaceutical Sciences, 2016, 11(6): 735-743.

DOI：10.1016/j.ajps.2016.05.008

• PAHy-based nanogel
• High drug loading
• Redox-responsivity
• Release properties
• Significant anti-tumor therapeutic efficacy

To achieve GSH-responsive 5-Fluorouridine (5-FU) delivery, a novel family of nanogel drug carriers has been successfully prepared. The new class of PAHy-based nanogels was prepared by the crossing-link reaction of poly-alpha,beta-polyasparthydrazide (PAHy) chains and 3,3'-dithiodipropionic acid (DTDPA) consisting of a redox-responsive chain network. This particle highlights recent efforts in introducing a disulfide bond to drug delivery nanogel by DTDPA, and the increased release properties of complex nanogels produced excellent glutathione (GSH)-sensitivity and significant anti-tumor therapeutic efficacy. The PAHy-based nanogels were characterized by Fourier transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS) (nano-particle size similar to 200 nm), UV-vis spectrometry, X-ray diffraction (XRD) and differential scanning calorimetric (DSC). PAHy-based nanogels are promising controlled-release carriers for the tumor-targeting delivery of the anticancer agent 5-Fluorouridine.

• 出版日期2016-12
• 单位沈阳药科大学