Antioxidant and antiproliferative activity of Hypericum hircinum L. subsp majus (Aiton) N. Robson essential oil

作者：Quassinti Luana; Lupidi Giulio; Maggi Filippo; Sagratini Gianni; Papa Fabrizio; Vittori Sauro; Bianco Armandodoriano; Bramucci Massimo^*

来源：Natural Product Research, 2013, 27(10): 862-868.

DOI：10.1080/14786419.2012.677044

• Hypericum hircinum L
• subsp
• majus (Aiton) N
• Robson
• Guttiferae
• essential oil
• antioxidant activity
• antiproliferative activity

This study was undertaken to assess the antioxidant and antiproliferative potential of the essential oil of Hypericum hircinum L. subsp. majus (Aiton) N. Robson. Analysis of the oil composition revealed that sesquiterpene hydrocarbons (69.3%) dominate, cis--guaiene, -selinene and (E)-caryophyllene being the most representative. Significant values of antioxidant activity were found using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radical scavenging assays. The essential oil revealed antiproliferative activity as evaluated on human glioblastoma (T98G), human prostatic adenocarcinoma (PC3), human squamous carcinoma (A431) and mouse melanoma (B16-F1) tumour cell lines by MTT assay.

• 出版日期2013-5-1