Behavior of soluble HLA-A, -B, -C and HLA-G molecules in patients with chronic hepatitis C virus infection undergoing pegylated interferon-alpha and ribavirin treatment: potential role as markers of response to antiviral therapy

作者：Murdaca Giuseppe; Contini Paola; Cagnati Paola; Marenco Simona; Pieri Giulia; Lantieri Francesca; Picciotto Antonino; Puppo Francesco^*

来源：Clinical and Experimental Medicine, 2017, 17(1): 93-100.

DOI：10.1007/s10238-015-0399-5

• Soluble HLA
• HLA-G
• HCV
• Interferon-alpha
• Ribavirin

The serum levels of soluble HLA class I antigens (sHLA-A, -B, -C and sHLA-G) were determined in 40 HCV genotype 1-infected patients before (T (0)), after 3, 6, and 12 months (T (3), T (6), and T (12)) of pegylated-IFN-alpha plus ribavirin therapy and 6 months (T (18)) after the end of treatment. Twenty patients were sustained virological responders (SVR), and 20 were non-responders (NR). sHLA-A, -B, -C levels at T (0) were significantly higher in both SVR (mean 10.48 mu g/ml) and NR (mean 11.87 mu g/ml) patients as compared to healthy controls (mean 0.34 mu g/ml, p < 0.0001) and HIV-infected subjects (mean 1.22 mu g/ml, p < 0.0001). sHLA-G levels at T (0) were significantly higher in SVR (mean 24.78 ng/ml) and NR (mean 24.93 ng/ml) patients as compared to healthy controls (mean 10.34 ng/ml, p = 0.015 and p = 0.014, respectively) but were lower as compared to HIV-infected subjects (mean 48.00 ng/ml, p < 0.0001). The levels of sHLA-A, -B, -C and sHLA-G significantly decreased in SVR from T (0) to T (18) (mean 1.64 and 1.43 ng/ml, respectively, p < 0.0001) and correlated with HCV-RNA, AST, ALT, gamma GT, and ALP levels. The determination of soluble HLA class I levels could be proposed as a surrogate marker to discriminate SVR and NR HCV-infected patients during PEG-IFN-alpha plus ribavirin therapy.

• 出版日期2017-2