A new spermidine macrocyclic alkaloid isolated from Gymnosporia arenicola leaf

作者：da Silva Gustavo; Martinho Ana; Soengas Raquel Gonzalez; Duarte Ana Paula; Serrano Rita; Gomes Elsa Teixeira; Silva Olga^*

来源：Fitoterapia, 2015, 106: 7-11.

DOI：10.1016/j.fitote.2015.07.020

• Gymnosporia arenicola
• Celastraceae
• Macrolactam ring
• Spermidine alkaloid
• Structural characterization

The isolation and structural elucidation of a macrocyclic alkaloid, characterized by the presence of a 13-membered macrolactam ring containing a spermidine unit N-linked to a benzoyl group is hereby reported. The structure of this previously unknown spermidine alkaloid isolated from Gymnosporia arenicola (Celastraceae) leaves has been elucidated by H-1 and C-13 NMR spectroscopy (including bidimensional analysis) and further characterized by high-resolution mass spectrometry and polarimetry. A route for the biosynthesis of this new bioactive macrocycle is proposed and the cytotoxicity of the compound was evaluated against two ATCC cell lines one normal-derived (MCF10A) and one cancer-derived cell line (MCF7) - using the MTT assay. The alkaloid revealed to be non-cytotoxic against both cell lines. The IC50 values from the cells were also determined.

• 出版日期2015-10
• 单位河北医科大学