Asymmetric Dimethyloarginin (ADMA) Concentration in the Aqueous Humor of Patients with Exfoliation Syndrome or Exfoliative Glaucoma

作者：Mikropoulos Dimitrios G; Mallini Paraskevi; Michopoulou Anna; Giannopoulos Theodoros; Arranz Marquez Esther; Koliakos Georgios G^*; Konstas Anastasios G P

来源：Current Eye Research, 2013, 38(2): 266-270.

DOI：10.3109/02713683.2012.757325

• ADMA
• aqueous humor
• exfoliation syndrome
• glaucoma
• oxidative stress X

Background: Asymmetric dimethyloarginin or dimethylarginin (ADMA) is a marker and maker of oxidative stress. It is elevated in several pathological conditions, such as hyperhomocysteinemia and endothelial dysfunction, which have also been reported in patients with exfoliation syndrome (XFS), or exfoliative glaucoma (XFG). We evaluated ADMA levels in the aqueous humor of XFS and XFG patients. %26lt;br%26gt;Methods: This study included 48 aqueous samples; 16 from cataract patients with XFS, 16 from cataract patients with XFG and 16 from age-matched cataract control patients. ADMA levels were determined employing a commercial ELISA kit. Results: ADMA concentration was significantly greater in XFG patients (0.398 +/- 0.026 mu M) compared to either XFS (0.168 +/- 0.028 mu M; p%26lt;0.0001) or normal cataract controls (0.245 +/- 0.025 mu M; p = 0.0002). In contrast, no significant difference was detected for ADMA levels in the aqueous of XFS patients as compared to normal controls (p = 0.0477). %26lt;br%26gt;Conclusions: Aqueous humor ADMA concentration is significantly elevated in XFG patients supporting the view that oxidative stress plays a key role in XFG pathobiology. The lower level of this marker in XFS suggests that the development of XFG is a prerequisite for ADMA elevation.

• 出版日期2013-2