Association of PPAR Alpha Intron 7 G/C, PPAR Gamma 2 Pro12Ala, and C161T Polymorphisms with Serum Fetuin-A Concentrations

作者：Markus Bernadett; Voros Krisztian; Supak Dorina; Melczer Zsolt; Cseh Karoly; Kalabay Laszlo^*

来源：PPAR Research, 2017, 2017: 7636019.

DOI：10.1155/2017/7636019

Background. Both peroxisome activator proteins (PPARs) and fetuin-A play a role in lipid and glucose metabolism. Aims. We investigated whether PPAR alpha intron 7 G2468/C and PPAR gamma 2 Pro12Ala and PPAR gamma exon 6 C161T polymorphisms are associated with serum fetuin-A concentrations. Patients and Methods. The PPAR alpha intron 7 G/C polymorphism was studied in cohort 1 (79 reference individuals, 165 postinfarction patients). The two PPAR gamma polymorphisms were investigated in cohort 2 (162 reference individuals, 165 postinfarction patients). Fetuin-A levels and PPAR polymorphisms were determined by radial immunodiffusion and polymerase chain reaction-restriction fragment length polymorphism techniques. Results. The C allele variant of PPAR alpha intron 7 G2467C was associated with higher fetuin-A levels (p = 0.018). Postinfarction status (p = 0.001), PPAR alpha intron 7 GG/GC/CC genotypes (p = 0.032), and the C allele (p = 0.021) were the strongest determinants of fetuin-A concentration in a multiple regression model. Higher fetuin-A levels were associated with the Pro variant of PPAR gamma 2 (p = 0.047). Postinfarction status (p = 0.041) and BMI (p < 0.001) but not PPAR gamma 2 Pro were the strongest determinants of fetuin-A concentrations. PPAR gamma exon 6 C161T genotypes were not associated with fetuin-A levels. Conclusions. Fetuin-A was determined mainly by the PPAR alpha intron 7C allele and postinfarction status in cohort 1 and the BMI and postinfarction in cohort 2. The PPAR alpha intron 7C and PPAR gamma 2 Pro variants are associated with fetuin-A levels.

• 出版日期2017