Atypical parakeratotic spires and HCIIHPV results: Correlation in liquid-based cervicovaginal cytology specimens interpreted as ASC-US

作者：Kubba Lena A; Patel Kumud; Du Hongyan; Hahn Elizabeth A; Sturgis Charles D^*

来源：Diagnostic Cytopathology, 2007, 35(8): 476-481.

DOI：10.1002/dc.20677

The 2001 Bethesda System (2nd edition) indicates that parakeratosis with nuclear enlargement, hyperchromasia, irregular contours, and/or three dimensionality should prompt consideration of an interpretation of ASC-US or greater. The authors retrospectively reviewed 812 liquid-based cervicovaginal cytology samples (CVCSs) interpreted as ASC-US during an H-month period. All slides were studied for the presence or absence of atypical parakeratotic spires (APKSs), a specific form of atypical parakeratosis. Results from corresponding Hybrid Capture II high risk (HR) HPV testing were recorded (blinded). Of 812 women, 28% (2301812) had APKSs and 20% (1631812) had positive HCH assays for HR HPV. Three percent of all reflexed ASC-US vials (261812) had both APKSs and positive HR HPV assays (sensitivity = 16%, specificity = 69%). APKSs in liquidbased CVCSs interpreted as ASC-US do not independently correlate to a positive reflex test for HR HPV (P < 0.0001). This suggests that APKSs are most often unrelated to underlying HR HPV infection. The finding of APKSs alone in CVCSs does not warrant an interpretation of SIL and should be used only in concert with other findings to label a sample as ASC-US.

• 出版日期2007-8
• 单位西北大学