Nanoparticles Based Carbon Paste Electrodes for the Determination of Flupentixol Dihydrochloride: Application to Pharmaceutical Analysis and Pharmacokinetic Study

作者：Abdallah Nehad A

来源：International Journal of Electrochemical Science, 2016, 11(12): 10715-10731.

DOI：10.20964/2016.12.04

• Flupentixol
• copper nanoparticles
• multiwall-carbon-nanotubes
• pharmacokinetics dissolution

Five different carbon paste electrodes were developed and applied for the electrochemical determination of flupentixol dihydrochloride. Sensor 1 was fabricated using a mixture of graphite powder and multiwall-carbon-nanotubes. Different additives were used to improve the performance and the sensitivity of the carbon paste electrode. Sensor 2 was developed using chitosan in addition to the graphite powder and the multiwall-carbon-nanotubes while sensor 3 was fabricated with the addition of calix[4]arene ionophore. Copper nanoparticles were incorporated in the membrane paste of sensor 4. Sensor 5 was fabricated using a mixture of copper nanoparticles, multiwall-carbon-nanotubes and calix[4]arene in a graphite paste. The studied carbon paste electrodes exhibited the best performance characteristics with slopes of 29.7, 28.8, 30.2, 30.7 and 30.8 (mV/concentration decade) and linear concentration ranges of 1.0 x 10(-5) - 1.0 x 10(-2), 1.0 x 10(-6) - 1.0 x 10(-1), 1.0 x 10(-7) - 1.0 x 10(-2), 1.0 x 10(-9) - 1.0 x 10(-2) and 1.0 x 1.0 x 10(-2) mol L-1 for sensors 1, 2, 3, 4 and 5, respectively. The sensors linear ranges deviated from their ideal ranges after 40, 46, 58, 63 and 82 days for sensors 1, 2, 3, 4 and 5, respectively. All the proposed sensors were successfully used for the determination of flupentixol dihydrochloride in bulk, tablets dosage forms and human plasma samples.

• 出版日期2016-12