Association of antinociceptive action of botulinum toxin type A with GABA-A receptor

作者：Drinovac V; Bach Rojecky L; Lackovic Z^*

来源：Journal of Neural Transmission, 2014, 121(6): 665-669.

DOI：10.1007/s00702-013-1150-6

• Botulinum toxin type A
• Neuropathic pain
• Formalin-induced pain
• GABA
• c-Fos

The mechanism of botulinum toxin type A (BTX-A) antinociceptive action in the central nervous system is little known. The potential interaction between BTX-A and GABAergic system has not been investigated previously. In the present study, we demonstrate prevention of BTX-A antinociceptive effect on formalin-induced inflammatory pain and partial sciatic nerve transection-induced mechanical allodynia by GABA-A antagonist bicuculline, thus suggesting association of the GABA-A receptors and antinociceptive action of BTX-A.

• 出版日期2014-6